is reconstitution solution the same as bacteriostatic water?

This information, including any referenced scientific or clinical research, is made available for educational purposes only. Some drugs can interact poorly with each solvent, and they are not considered universally interchangeable in clinical contexts. PDF Zomacton Description pose a threat of fluid overload except possibly in very small infants. Dosage form: injection, solution By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Use only as a diluent or solvent. Other side effects can include low blood sodium also known as hyponatremia, fluid overload, allergic reactions (tightness in the chest, swelling of the mouth, face, and lips) fever, redness at the site of injection as well as electrolyte imbalance. Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. The re-use of sterile water for injections is strictly prohibited. What is bacteriostatic water? This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. It also is prepared with a bacteriostat, a compound used to prevent any bacterial growth. and PRECAUTIONS sections. The site is secure. If the peptide still doesnt get dissolved, perform trial and error and use various other solvents. 62.5 mg/mL, 3.2 mL b. Correctly reconstituting peptides is essential in their effectiveness. If I have a 2mg bottle how much water total do I put into the vial? The benzyl alcohol in the water makes bacteriostatic water ideal for diluting any drug that will be administered by intramuscular, intravenous, or subcutaneous injection. If kept under appropriate conditions, bacteriostatic saline can last up to 28 days. . Parenteral preparations with benzyl alcohol should not be used for fluid replacement. It is only used for injections such as intravenous, intramuscular and subcutaneous. Bacteriostatic water formulations for injection have pH levels of 4.5-7, averaging 5.7. But dont get too excited just yet. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. Made with Muscle. Reconstitution Definition: 569 Samples | Law Insider Management of Drug Shortages with 0.9% Sodium Chloride, Sterile Water The following preparation is designed solely for parenteral use only after addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injection. In a nutshell, in order to make the 1 proper dosage of BPC-157, you would need to draw 10 units of water and then mix it by following the reconstitution guidelines. Acidic peptides will be best soluble in basic solution and vice versa. To the extent that Peptides.org references a product that is also a prescription medication, Peptides.org does not does not offer medical diagnosis or treatment advice. Overdose & Contraindications OVERDOSE Use only as a diluent or solvent. Contraindications for bacteriostatic water injections include newborn babies and cerebrospinal injections [2, 8]. SIDE EFFECTS. These formulations are less expensive to produce and more widely available than comparable products, such as sterile water [3]. corrective measures. Read the full review on BPC 157 only at Muscle and Brawn. Selective Estrogen Receptor Modulator (SERM), Induction of Ovulation with CLOMIMED 50 (Clomiphene Citrate), Anemia in Cancer Patients: treatment with DECAMED 250 (Nandrolone Decanoate), PROVIMED 25 (Mesterolone) for the Treatment of Male Infertility. Differences Between Bacteriostatic Water vs. Sterile Water However, this method requires special equipment and expertise. Both meet US Pharmacopeia (USP) standards. 51.222.156.250 These Terms will be governed by and interpreted in accordance with the laws of the State of New York, and you submit to the non-exclusive jurisdiction of the state and federal courts located in New York for the resolution of any disputes. The Buckle LLC is allowed to assign, transfer, and subcontract its rights and/or obligations under these Terms without any notification. Bacteriostatic Water for Injection Prescribing Information. Penetrate the peptide vial as gently as you can. Peptide Reconstitution + Mixing Guide With Calculator - Muscle and Brawn Not only is this inefficient, but you may come across low-quality products from inferior manufacturers. In order to reconstitute 10 equal dosages, we need to mix 1ml of bacteriostatic water in all the 10 injections, which means 0.1ml of water per dosage. Data are unavailable on the toxicity of other preservatives in this age group. This significantly reduces the risk of infection [, It is an efficient solvent and presents minimal interaction with most medications [, Apart from medications, bacteriostatic water is also indicated for the reconstitution and injection of therapeutic research peptides and hormones [, Suitable injection routes are determined by the type of solute, the recipients needs, and target rates of diffusion and metabolization. Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. Curious about Bacteriostatic Water for injections? Always use as directed on the label. Peptide Reconstitution + Mixing Guide with Calculator, Read the full review on BPC 157 only at Muscle and Brawn, Limitless Life Nootropics (and Peptides) Review, Epitalon Peptide Guide: Benefits, Uses, Dosage, How to Safely Use SARMs to Sculpt Three-Dimensional Muscles and Torch Fat, The ONE Thing You MUST do Before starting SARMs if You Want to Keep Yourself Out of the Hospital, The MILDEST SARM that gives you gains without all the bloating, How to Properly Use SARMs to build 3D Muscles Without Experiencing Sloppy Noodle Syndrome. Peptide reconstitution is a complicated and confusing process for many. Using Bacteriostatic Water vs. Sterile Water - Paradigm Peptides Some peptides are still off-limits to us mere mortals, and only available for research purposes. Data sources include IBM Watson Micromedex (updated 1 May 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Reconstitution Solution 4-Pack (30mL) Bactostatic Labs. Typically available as lyophilized powders to maintain purity and integrity, peptides require reconstitution before injection [12]. 5.161.53.20 ITG SUBJECT: LYOPHILIZATION OF PARENTERALS. First, lets break down the basics of sterile water. Touched on earlier, another key difference is multiple uses. False Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. You must not use this Website if you disagree with any of these Website Standard Terms and Conditions. Exogenous formulations are available in powder and liquid forms. Certain areas of this Website are restricted from being access by you and Buckle LLC may further restrict access by you to any areas of this Website, at any time, in absolute discretion. Purchase your full kit today to safely use bacteriostatic water for injections. As discussed earlier, peptide mixing water is used to dissolve/dilute the lyophilized peptides. For intravenous or intramuscular injection, prepare solution by aseptically adding not more than 2 mL of Bacteriostatic Water for Injection or Bacteriostatic Sodium Chloride Injection to the contents of one vial. This monograph has been modified to include the generic and brand name in many instances. Bacteriostatic Water (bacteriostatic water for injection) is a highly purified, sterilized water containing 0.9% benzyl alcohol that is used to dilute or dissolve medications to the appropriate consistency for injection. I recommend using bacteriostatic water since that's what the peptide vendors sell and recommend. See PRECAUTIONS. Benzyl alcohol can be a topical irritant but in the concentration of 0.9% does not typically cause irritation and may provide some anesthetic effects. Failure to do so risks the development of hemolysis, damaging the red blood cells [9, 10]. Some drugs for injection may be incompatible in a given vehicle, or when combined in the same vehicle or in a vehicle containing benzyl alcohol. This website is using a security service to protect itself from online attacks. While there is no fixed dosage of peptides and each peptide accounts for a different dose. After that, collect and prep your materials. Bacteriostatic Water vs reconstitution solution whats the difference? For these types of products, bioburden should be minimal and the bioburden should be determined prior to sterilization of these bulk solutions prior to filling. The packaged diluent (Bacteriostatic Water for Injection) contains benzyl alcohol as a preservative. While most of the peptides will be soluble in bacteriostatic water and sterile water, some really wont, and this will be depending on the polarity of the peptides. Once you open the seal of the sterile water vial, you will either have to use it preferably within the next 4 hours or discard it. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Many people have this mentality that bacteriostatic water and sterile water are the same thing, and that can bring disastrous results. All of our content is written by people with a strong science background, including medical researchers. Bacteriostatic Water for Injections | The A-Z Guide Before sharing sensitive information, make sure you're on a federal government site. You can email the site owner to let them know you were blocked. It is essential to avoid repeated freeze-thaw cycles and exposure to light and high temperatures. So, if you are someone who has seen the vials of both types of water, I am sure you can now understand why a bacteriostatic water vial contains considerable volume while a sterile water vial contains just a few milliliters. .063 mg/mL, 3200 mL c. 1000 mg/mL, 5 mL d. 64 mg/mL b. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Performance & security by Cloudflare. The benzyl alcohol in it would cause red blood cell lysis. How to use reconstitute in a sentence. When reconstituted with Bacteriostatic Water for Injection, USP, the resulting solution must be used within 7 days. As it cannot transfer pathogens, it is used mainly used in the medical field. swelling of your face, lips, tongue, or throat, redness, warmth, and pain at the injection site, tenderness or irritation at the injection site. Once you have put the details, our reconstitution calculator will use its algorithm and devise the volume needed to get your peptides reconstituted! These Terms will be applied fully and affect to your use of this Website. Based on 26 documents. Made with the organic preservative benzyl alcohol, this solution resists contamination to enable multiple doses per vial. If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate countermeasures, and if possible, retrieve and save the remainder of the unused vehicle for examination. Long-term storage: For long-term storage, it is recommended to aliquot the reconstituted peptide into small volumes and freeze them at -20C or -80C. Create your account and enjoy a new shopping experience. It is a copolymer of ethylene and propylene. For the reconstitution of HGH powder, bacteriostatic water is a great choice, as it preserves HGH solutions and efficiently dissolves lyophilized aggregates [16]. You are granted limited license only for purposes of viewing the material contained on this Website. You use AA, wich is a .6% solution of acetic acid. Your IP: Lets explore their points of similarity and difference to understand their appropriate uses. Because most peptides are sold in powder form, one needs to dissolve/dilute them before really using them. Handlers should adhere to the exact indications or medical instructions. Although products may be labeled for reconstitution with Bacteriostatic Water for Injection, Sterile Water for Injection (WFI) should be used to reconstitute products. Because different stoppering equipment is required, stoppers are sometimes placed on vials by operators rather than by machine. Daptomycin: a comparison of two intravenous formulations For those of you thinking about the volume of water, 1ml is usually enough for all the peptides available in the market. Although rarely, but they can occur, those side effects are more related to the drug that is dissolved in the bacteriostatic water. Use aseptic technique for single or multiple entry and withdrawal from all containers. (I would personally recommend bacteriostatic water because of its longer shelf-life). Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. You can go as high as 2 milliliters per peptide reconstitution as it does no harm other than more dilution. Bacteriostatic Water vs "reconstitution solution" what's - Reddit Some of the important aspects of these operations include: the formulation of solutions; filling of vials and validation of the filling operation; sterilization and engineering aspects of the lyophilizer; and testing of the end product. The semi-rigid vial is fabricated from a specially formulated polyolefin. On the other hand, TB-500, another potential peptide for quick healing is usually dosed at 7.66mg per week. Gather the following: alcohol swabs, bacteriostatic water, peptide powder, and a sterile syringe. A generally recognized acceptable method of sterilizing the lyophilizer is through the use of moist steam under pressure. The .gov means its official.Federal government websites often end in .gov or .mil. This process is often helpful in breaking down the big solid lumps of peptides in the water and aids in the dissolution process. Bacteriostatic water is very easy to manufacture while sterile water is an arduous process. Due to the bacteriostat, bacteriostatic water comes in a multi-dose formulation for multiple uses. Do not use unless the solution is clear and seal intact. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Bacteriostatic waters preservative content prevents contamination for multiple doses, while sterile water may be contaminated after one use. It may be wise to always opt for bacteriostatic water if both water types are allowed for use. Another key difference is availability. You should never inject bacteriostatic water without mixing in any medications because the benzyl alcohol in it causes the red blood cell lysis. Note that you should absolutely not stir or shake the vial as it is going to damage the peptide and it will no longer be effective. We do the complete research and follow standards before starting the manufacturing process. and ADVERSE REACTIONS. That being said, using any old water to reconstitute it is a big no-no. Specialists generally consider bacteriostatic water to be a more efficient solvent or dilutant. Step 1: Wash your hands and gather your materials. I am sure that most of the things would be clear by now. and our ResearchPeptides.org follows the strictest sourcing guidelines in the health and nootropics industry. My recommendation is to use bacteriostatic water as that's what most peptide vendors sell. If an adverse reaction does occur, discontinue the infusion, evaluate . But, if there is an absolute need to stock solution form, what I would recommend is to store the required dosage into individual vials. The small volume of fluid provided by Bacteriostatic Water for Injection, USP when used only as a pharmaceutic aid for diluting or dissolving drugs for parenteral injection, is unlikely to exert a significant effect on fluid balance except possibly in very small infants. Lets just assume that you have been prescribed 500mcg of BPC 157. did you ever get an answer? Example would be 5g of CJC-1295 and 5g of ipamorelin. Provisions for sterilizing the inert gas or air supply lines. All Right Reserved. A major difference between the two is the patient population. In case you experience any of these side effects, you should immediately stop using sterile water for injections and talk to a doctor. Flamberg, DW; "Manufacturing Considerations in the Lyophilization of Parenteral Products"; Pharmaceutical Manufacturing, Volume 3, No. Both substances are sterile solvents formulated for use in medical settings. Buckle LLC, including its officers, directors and employees shall not be held liable for any indirect, consequential or special liability arising out of or in any way related to your use of this Website. The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. Reconstitution Definition & Meaning | Merriam-Webster Medical Once vials are partially stoppered, they are transported to the lyophilizer. This Website is provided as is, with all faults, and Buckle LLC express no representations or warranties, of any kind related to this Website or the materials contained on this Website. Performance & security by Cloudflare. Although adverse reactions to intravenous, intramuscular or subcutaneous injection of 0.9% benzyl alcohol are not known to occur in man, experimental studies of small volume parenteral preparations containing 0.9% benzyl alcohol in several species of animals have indicated that an estimated intravenous dose up to 30 mL may be safely given to an adult without toxic effects. If you feel that any of our content is inaccurate or out-of-date, please contact us at: [emailprotected]. Your IP: Well, people have been mixing peptides in the same syringe and then administering them. Other than the content you own, under these Terms, Buckle LLC and/or its licensors own all the intellectual property rights and materials contained in this Website. How to Mix HCG (Human Gonadotropin) - Defy Medical Bacteriostatic Water (bacteriostatic water for injection) is a highly purified, sterilized water containing 0.9% benzyl alcohol that is used to dilute or dissolve medications to the appropriate consistency for injection. 420 Throckmorton Street, Suite 200, Fort Worth Texas 76102, Copyright 2022 BacteriostaticWater.com - All Rights Reserved, Wholesale Hospira Bacteriostatic Water Supplier, Need help? Most peptides that you will see are often sold as lyophilized peptides which means that (freeze-dried) powder form. According to a recent study, 99.9% of people struggle with this step. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. Medications that required diluting with water usually indicate on the bottle which water is preferred for use. If you are a peptide researcher or laboratory professional, you can safely enjoy the benefits of bacteriostatic water with proper use. Intravenous administration of Bacteriostatic Water for Injection without a solute may result in hemolysis. Another difference is indications. One vial of BPC 157 contains 5mg, which also means 5000mcg. (WITHOUT GRABBING YOUR FREE COPY OF THE SARMS AND PEPTIDES SECRETS MINI COURSE). Both may be used in the injection of peptides, hormones, and various medications, often reconstituted from lyophilized powder. Please refer to the WARNINGS While there is not a long-term shortage, an acute shortage is often seen because of either manufacturing facilities malfunction or some medical emergency such as COVID-19. All you have to do is just follow the easy steps and BOOM! Haven't had any problems with this bacteriostatic water. Would love your thoughts, please comment. Two independent temperature sensing systems. When preparing bacteriostatic water for injection, all product indications should be closely followed, including recommended dosages and injection schedules [4]. Bacteriostatic Water may be used alone or with other medications. Besides neonates, they both can be used for the rest of the population including pediatrics, adults and the geriatric community. However, if you can get your hands on some, then congratulations, youre already ahead of the game! Privacy Policy. Its like theyre a personal trainer, a nutritionist, and a beauty expert all rolled into one! Please let me know if you get an answer. 3) Choose the size of the syringe you want . Water for Injection, USP is chemically designated H2O. Mrose . When in liquefied form, the somatropin substancesare very delicate. The container requires no vapor barrier to maintain the proper labeled volume. First, you want to thoroughly wash your hands with soap and water for at least 20 seconds. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. The action you just performed triggered the security solution. So, the former is available in multi-dose containers that are viable for up to 28 days after opening, while sterile water comes in single-dose vials. When necessary, the pH of each formula was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7 to 8 and the tonicities are, for the 40 mg per mL . Both act as dilutants or solvents of substances to enable injection. if a dosage is say 20mcg of each individually, wht is a dosage of the mix? This guide has you covered. With a deluxe kit, you will have all you need for safe injections at your disposal. Buckle LLC is permitted to revise these Terms at any time as it sees fit, and by using this Website you are expected to review these Terms on a regular basis. Data are unavailable on the toxicity of other preservatives in this age group. Unused vials can remain viable for years with proper storage [4]. Remove Advertising. Water balance is maintained by various regulatory mechanisms. Store at 20 to 25C (68 to 77F). SOLU-CORTEF Dosage and Administration (hydrocortisone sodium succinate Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. The first step is to use the alcohol swab and wipe the vials containing lyophilized peptides and the bacteriostatic/sterile water. There is no sort of preservative or antimicrobial agent added to it. Plus, peptide solutions made with bacteriostatic water resist contamination. It is always advisable to carefully read them before trying to reconstitute the peptides. However, they do differ in their composition as the bacteriostatic water contains 0.9% benzyl alcohol as a preservative. Parenteral drug products should be inspected visually for particulate matter An official website of the United States government, : The pH is 5.7 (4.5 to 7.0). Before digging deeper into precise conditions required to store peptides, you should know that keeping a peptide vial away from intense light, high temperature and moisture is a MUST. Unfortunately, piping such as that for the administration of inert gas (usually nitrogen) and sterile air for backfill or vacuum break are often inaccessible to such surface "sterilization" or treatment. We partner major pharmaceutical companies in India & abroad as a reliable and efficient contract manufacturer. Some measures are necessary - do not inject the water straight into the powder with force, usually, do not drop or shake a reconstituted vial. You may report side effects to FDA at 1-800-FDA-1088. They both are USP meaning they have an official monograph or documentation by the United States Pharmacopeia, both are not used for IV solutions. On the other hand, a sterile water vial doesnt contain any preservatives/additives which can keep it free of pathogens for a longer time, thus one will have to use it immediately after opening the seal. To do the reconstitution of PT-141 you will need: Vial of PT-141 Vial of bacteriostatic water (or sterile water) Generally, lyophilizers should be sterilized after each cycle because of the potential for contamination of the shelf support rods. Parenteral preparations containing benzyl alcohol should not be used in epidural or spinal anesthesia procedures.